© 2018 The Australasian College of Dermatologists. What are the treatments for alopecia universalis Do home remedies work for alopecia universalis Can alopecia universalis be treated with a hair transplant What happens if alopecia goes untreated Alopecia universalis is a rare condition that results in the complete loss of hair on the scalp, face, and body. Updated on AugKey takeaways: Alopecia areata is when your immune system starts attacking your hair follicles. Future RCTs should be adequately powered and employ clearly defined clinical response endpoints to allow future meta-analyses.Īlopecia areata biological therapy drug therapy glucocorticoids hair diseases immunomodulation review. Evidence does not support the use of oral zinc sulphate, alefacept and efalizumab. The current evidence suggests efficacy of oral prednisolone pulse therapy and oral inosiplex. There is currently no specific systemic therapy that is supported by robust body of evidence from RCTs. Relapse rates were considerable in the four studies that reported this outcome. Adverse events were reported in 13 studies and were corticosteroid related or otherwise well tolerated. No study evaluated the impact of pharmacotherapy on quality of life using complete quantitative quality of life instruments. There was significant variability in the definition of treatment success. The most frequently investigated therapy was oral prednisolone pulse therapy and oral inosiplex. A total of 15 different systemic therapies were investigated. It is an advanced form of alopecia areata, a condition that causes round patches of hair loss. We found eight placebo-controlled RCTs, three RCTs comparing two systemic treatments and five RCTs comparing three treatments. Alopecia universalis (AU) is a condition characterized by the complete loss of hair on the scalp and body.

Alopecia universalis does not permanently damage the hair follicles. Sixteen studies were included with a total of 768 participants. There is currently no cure for alopecia universalis. All randomised controlled trials (RCTs) that evaluated the effectiveness of systemic treatments for individuals with alopecia areata, totalis or universalis were included. A systematic search was conducted of the peer-reviewed literature published between 1946 and March 2018 via Medline, Embase, Amed, the Cochrane Central Register of Controlled Trials, PsychINFO and Lilacs. In this systematic review, we evaluated the evidence surrounding systemic treatments for alopecia areata, alopecia totalis and alopecia universalis. This form of alopecia causes complete hair loss over the entire body. A range of systemic treatments are used for alopecia areata with variable evidence supporting efficacy. Alopecia totalis is also different from the most severe form of alopecia areata, known as alopecia universalis.

Alopecia areata universalis treatment